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Jimmy Carter has died at 100; longest-lived U.S. president4 hand 。

No. 3 Notre Dame women rout Virginia for Olivia Miles’ 100th career winThallium-201 Market Set for Exceptional Growth from 2024 to 2032

Meet This New AI Stock That Could Become a Wall Street Darling in 2025. It Has the Full Support of Nvidia and Trades at a Massive Bargain.A new wave of AI development is about to take shape — and Wall Street is starting to divert its attention from the market's largest companies to a different group of stocks, according to Bank of America. In a recent note, the bank's strategists said they foresaw a coming "Agentic AI wave," referring to the second phase of development. Possible beneficiaries include companies that are beginning to deploy AI through apps, or industrial and commercial robots. There are some signs AI innovation is already headed in that direction, the bank added, pointing to new features added to AI software, like Google's , and robotic security dogs being deployed at Trump's Florida Mar-a-Lago. Meanwhile, Bank of America clients are already beginning to shift their focus from the market's top AI names, like , to what the bank believes to be the "second phase of AI beneficiaries," the note said. "We urge investors not to diminish AI's near-term disruption potential in this early stage. Upside is unlikely to be fully priced in across the AI investment stack and, specifically, across our software coverage, in our view," strategists wrote. "We expect AI monetization across our coverage to begin in 2025 as software's AI moment arrives and monetization to become meaningful in 2026 as enterprise adoption accelerates," they continued. The bank reiterated its focus on six large-cap stocks, which it said were among its top picks as the Agentic AI theme plays out. 1. Microsoft ( ) In an early November note, the bank pointed to Microsoft's plans to supplement with more AI agents, which could help automate tasks related to sales, services, finances, and managing supply chains. Strategists issued a price target of $510 a share, implying 23% upside from current levels. 2. Salesforce ( ) Salesforce plans on integrating AI agents into its range of products, which can help automate tasks in areas like customer service and marketing, the bank said. The firm also finalized a partnership with Nvidia to create avatars that can automate tasks in customer service, crisis management, and other areas. Strategists issued a price target of $390 a share, implying 14% upside from current levels. 3. Adobe ( ) Adobe is planning to work AI tools into its product suite, including its Creative Cloud and Experience Cloud platforms. That can help automate tasks related to data analysis and creating new content, strategists said. Bank of America issued a price target of $640 a share, implying 20% upside from current levels. 4. ServiceNow ( ) The company is planning to deploy AI agents on its Now Platform, which can help in areas like IT management and customer service. Strategists issued a price target of $1,075 a share, implying 1% upside from current levels. 5. Intuit ( ) Intuit is also planning to integrate its AI agent across its range of products, which includes TurboTax, Credit Karma, and QuickBooks. That can automate tasks for users and businesses, like creating new bills or processing invoices. Strategists issued a price target of $780 a share, implying 21% upside from current levels. 6. HubSpot ( ) The firm is planning to deploy an AI agent into its Marketing and Content Hub, which will help automate tasks in areas like marketing and sales. Strategists issued a price target of $780 a share, implying 6% upside from current levels. Read the original article on

NoneWith Jagjit Singh Dallewal's indefinite hunger strike entering its 34th day on Sunday, farmer leaders at Khanauri said they have been following the Gandhian way to continue their protest and it is up to the government to decide whether it wants to use force to evict their senior leader. Their statement comes amid the Supreme Court's strong criticism of the Punjab government for not shifting Dallewal to a hospital. ET Year-end Special Reads What kept India's stock market investors on toes in 2024? India's car race: How far EVs went in 2024 Investing in 2025: Six wealth management trends to watch out for The farmers have been protesting at the Punjab-Haryana border to press the Centre for several demands, including a legal guarantee for a minimum support price (MSP) for crops. Speaking to reporters at the Khanauri border protest site, farmer leader Abhimanyu Kohar said, "We want to make it clear that the Centre, right from day one, has been trying to defame and suppress our agitation." He said a narrative is being built that farmers are stubborn. "Whereas it is the Centre that is adopting such an attitude, not listening to us and not paying any attention to farmers' demands." "We are continuing our agitation by adopting Gandhian principles. Our agitations have proven that, despite enduring so much due to the government's oppression, we have continued to protest in a Gandhian manner," he said. 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Now, it is up to the government and constitutional bodies to decide whether they want to use force to evict Dallewal ji," Kohar added. He further said the farmers wanted to make it clear that whatever situation arises, the responsibility will lie with the Centre and constitutional bodies. "We also want to appeal to the people of the country that the agitation seeking a guarantee for MSP has reached a decisive stage. We are on the threshold of victory... We must take a strong stand. Dallewal has put his life at stake," he said. Kohar said it was up to the people of the country to decide whether to stay at home or be present in large numbers at the Khanauri Morcha in support of Dallewal. SKM (Non-political) leader Kaka Singh Kotra said the government can try to evict Dallewal from the current protest site and their unions are appealing to Punjabis to reach Khanauri in maximum numbers. He also said Dallewal has made it clear that he is ready to sacrifice his life for the sake of farmers in this country. Meanwhile, farmers, on a warpath against the Centre, called for a "kisan mahapanchayat" at the Khanauri protest site on January 4. Samyukta Kisan Morcha (Non-political) and Kisan Mazdoor Morcha have also called for a Punjab bandh on Monday and claimed their strike call has received strong support from transporters, employees, traders, and other sections of society. Though there will be a complete bandh on Monday, emergency services will remain operational, farmer leader Sarwan Singh Pandher said. On Saturday, while admonishing the Punjab government, the Supreme Court also suggested the possibility that Dallewal may not have been allowed to be taken to a hospital by other farmer leaders. In response, Dallewal, in a video message on the same day , said, "I am sitting on a fast. Who gave this report to the Supreme Court, and who spread this misconception that I have been kept hostage? Where did such a thing come from?" "Seven lakh farmers in this country have committed suicide due to debt. Saving farmers is necessary, therefore, I am sitting here. I am not under anyone's pressure," he added. Dallewal had earlier said he would not break his fast until the government agreed to the farmers' demands. The Supreme Court gave the Punjab government time until December 31 to persuade Dallewal to shift to a hospital, granting the state the liberty to seek logistical support from the Centre, if necessary. In response the Punjab government said in the court that it is facing significant resistance from the protesting farmers, who have encircled Dallewal and are preventing him from being taken to a hospital. The apex court also termed the conduct of some farmer leaders accompanying Dallewal as surprising and questionable. Dallewal has so far refused medical treatment, and the state government has formed a team of doctors to monitor his health round-the-clock. Farmers, under the banner of SKM (Non-Political) and Kisan Mazdoor Morcha, have been camping at the Shambhu and Khanauri border points between Punjab and Haryana since February 13, after their march to Delhi was stopped by security forces. A "jatha" (group) of 101 farmers attempted to march to Delhi on foot three times between December 6 and 14 but were stopped by security personnel from Haryana. In addition to a legal guarantee for MSP, the farmers are demanding a debt waiver, pensions for farmers and farm labourers, no hike in electricity tariffs, the withdrawal of police cases, and "justice" for the victims of the 2021 Lakhimpur Kheri violence. (You can now subscribe to our Economic Times WhatsApp channel )Apple Unveils AI-Powered Update with Custom Emojis for iPhones

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Call of Duty: Warzone developers have once again removed the COR-45 pistol from action until further notice. The COR-45 handgun has been a fan-favorite secondary since its introduction in WZ and Modern Warfare 3, despite the many issues that often plague it. Developers temporarily restricted the sidearm’s XRK IP-V2 Conversion Kit in July 2024 due to an error that resulted in an unintentionally high fire rate. Trouble struck again in August since a glitch for the same kit gave the COR-45 an Akimbo attachment . Now the pistol must sit on the sidelines once more, as Warzone developers work out a way to resolve its latest string of issues. Call of Duty devs have disabled the COR-45 in Warzone In a post on the Call of Duty Updates X account, developers announced the removal of the COR-45 as of December 23, 2024. “The COR-45 handgun has been restricted until further notice,” reads the message in full, meaning there is currently no word on when players should expect the fan-favorite sidearm to return. Notably, the COR-45’s return to the game unlocked a secondary meta that quickly made the weapon OP. Players found that removing aftermarket parts from the Cork and Screw blueprint , then adding attachments like the XRK Tactical Stock basically turned Warzone’s COR-45 pistol into a fast-firing SMG. As mentioned above, similar glitches have broken the pistol’s functionality in the past. How it was able to return in a still-broken state is anyone’s guess at this point. For now, though, the COR-45’s sudden removal prevents players from abusing the glitch. Related: Black Ops 6 and Warzone are currently in Season 1, with Season 2 scheduled to kick off on Tuesday, January 28, 2025. What developer Treyarch has planned for the new season of content presently remains a mystery, so Warzone faithful can only hope the COR-45 will be reinstated by then.

ANKARA, Turkey (AP) — Ethiopia and Somalia agreed on Wednesday to hold “technical talks” to resolve a dispute sparked by Ethiopia’s deal with Somalia's breakaway region of Somaliland, according to a statement following talks in Turkey. Read this article for free: Already have an account? To continue reading, please subscribe: * ANKARA, Turkey (AP) — Ethiopia and Somalia agreed on Wednesday to hold “technical talks” to resolve a dispute sparked by Ethiopia’s deal with Somalia's breakaway region of Somaliland, according to a statement following talks in Turkey. Read unlimited articles for free today: Already have an account? ANKARA, Turkey (AP) — Ethiopia and Somalia agreed on Wednesday to hold “technical talks” to resolve a dispute sparked by Ethiopia’s deal with Somalia’s breakaway region of Somaliland, according to a statement following talks in Turkey. Turkey has been mediating between the two east African countries as tensions between them have simmered since Ethiopia signed a memorandum of understanding with Somaliland in January to lease land along its coastline to establish a marine force base. In return, Ethiopia would recognize Somaliland’s independence, which Somalia says infringes on its sovereignty and territory. A joint declaration was reached after Turkish President Recep Tayyip Erdogan met separately with Somali President Hassan Sheik Mohamud and Ethiopian Prime Minister Abiy Ahmed on Wednesday. It says the sides agreed the talks, which would begin by February 2025 and conclude within four months, would respect Somalia’s territorial integrity while recognizing “potential benefits” of Ethiopia’s access to the sea. The declaration also says the sides would work to “finalize mutually advantageous commercial arrangements” to allow Ethiopia “to enjoy reliable, secure and sustainable access to and from the sea,” under Somalia sovereignity. Somaliland seceded from Somalia more than 30 years ago, but is not recognized by the African Union or the United Nations as an independent state. Somalia still considers Somaliland part of its territory. Over the years, Somaliland has built a stable political environment, contrasting sharply with Somalia’s ongoing struggles with insecurity amid deadly attacks by al-Qaida-linked militant group al-Shabab. In November, Somaliland held a presidential election that gave a boost for its push for international recognition. With a population estimated at over 120 million, Ethiopia is the most populous landlocked country in the world. Turkey has previously hosted two rounds of talks between the African nations’ foreign ministers but a third round, expected in September, was delayed, raising concerns of escalating tensions. Erdogan, flanked by Mohamud and Abiy, told reporters at a late night news conference in the Turkish capital, Ankara, that the sides have reached an “important stage” in efforts to solve their dispute. The joint declaration, Erdogan said, focuses “on the future and not the past.” “By overcoming some resentments and misunderstandings, we have taken the first step toward a new beginning based on peace and cooperation between Somalia and Ethiopia,” Erdogan continued. He also said he hoped Somalia would take steps to give Ethiopia sea access. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. Abiy, the Ethiopian prime minister, insisted that “Ethiopia’s aspiration for secure access to the sea is a peaceful venture and one that would benefit all our neighbors.” “I believe that today’s constructive discussions will push us into a new year with this spirit of cooperation, friendship and the willingness to work together instead of against each other,” he said. Somalia’s president said the Horn of Africa is a “very fragile and very volatile region, which needs both Ethiopia and Somalia to work together” for the benefit of both. Turkey has forged close ties with Somalia, and recently also signed deals toward cooperation in defense and oil and gas exploration. It also has economic and trade ties with Ethiopia. A Somaliland opposition leader, Abdirahman Mohamed Abdullahi, who had been critical of the deal with Ethiopia, won the November election. He is to be inaugurated on Thursday. Advertisement Advertisement

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French President Emmanuel Macron named a new government Monday evening, putting together a team under Francois Bayrou, his fourth prime minister of the year, to drag the second-largest EU economy out of political crisis. Macron named former prime minister Elisabeth Borne, 63, education minister in a new cabinet under centrist Bayrou, announced Elysee secretary-general Alexis Kohler. Another former premier, Manuel Valls, 62, returned as overseas territories minister, while former interior minister Gerald Darmanin became justice minister. Both Defence Minister Sebastien Lecornu and Foreign Minister Jean-Noel Barrot kept their jobs, the presidency said. Lecornu, a 38-year-old loyalist with a keen political nose, has served in every government since Macron's first election as president in 2017. Conservative Interior Minister Bruno Retailleau, who has vowed to crack down on illegal immigration, and right-wing Culture Minister Rachida Dati, also stayed in their posts. The difficult job of delivering a budget plan for next year falls to Eric Lombard, head of public-sector lender Caisse des Depots (CDC), who was named economy minister. "I'm very proud of the team we're presenting this evening," Bayrou said on X, adding his "experienced" cabinet would aim to "rebuild trust". The inclusion of two former prime ministers indicates Macron's desire for a heavyweight government that will enjoy stability and not share the fate of Bayrou's predecessor, Michel Barnier, ousted in a no-confidence vote. Bayrou had hoped to bring in figures from the left, right and centre to protect his government from possible censure, but his 35-member team does not include any members of the left-wing coalition New Popular Front. Macron will assemble Bayrou's team on January 3 for a first Council of Ministers meeting, the presidency said. Barnier was brought down over his failure to win support for an austerity budget to shore up France's shaky finances with spending cuts and tax rises. The priority for 73-year-old Bayrou is to make sure his government can survive a no-confidence vote and that it passes a cost-cutting budget for 2025. The unexpected comeback of Valls, premier from 2014 to 2016, as the head of the overseas territories ministry indicates the importance of the post after authorities were strongly criticised for their response to the deadly cyclone on the Indian Ocean territory of Mayotte, which killed at least 35 people. Darmanin had long been known to covet the post of foreign minister, but after days of intense discussions will have to content himself with the justice ministry. Just before the official announcement, heavyweight right-wing politician Xavier Bertrand, who had been tipped for the health ministry, announced he would not be part of the government. He alleged that it had been formed with the implicit "backing" of far-right leader Marine Le Pen, who will play a key role in ensuring its survival. "The prime minister informed me this morning, contrary to what he had proposed yesterday, that he was no longer in a position to entrust me with responsibility for the justice ministry due to opposition from (Le Pen's) National Rally," Bertrand said in a statement. "Despite his new proposals, I refuse to take part in a government of France formed with the backing of Marine Le Pen." Bertrand is a major irritant for the far right, which he has long opposed. Le Pen on March 31, 2025 faces the verdict in an embezzlement trial on charges she denies. If convicted, she could lose the chance of standing in the 2027 elections and with it her best chance yet of winning the presidency. The announcement came as France observed a day of mourning for victims in cyclone-hit Mayotte, France's poorest overseas territory. Bayrou, the head of the centrist MoDem group, which is allied to Macron's party, was appointed on December 13. He is the sixth prime minister of Macron's mandate. Many already predict Bayrou will struggle to survive. France has been mired in deadlock since Macron gambled on snap elections this summer in the hopes of bolstering his authority. The move backfired, with voters electing a parliament fractured between three rival blocs. Le Pen suggested Macron has been weakened by months of political crisis and would eventually have to resign. "I am preparing for an early presidential election," she told French newspaper Le Parisien last week. bur-as/jhbMexico president hails 'excellent' Trump talks after US tariff threatCan ordinary citizens solve our toughest problems?

Gauge Protection Design: Enhancing Drilling Performance and Wellbore Stability. 12-23-2024 07:30 PM CET | Industry, Real Estate & Construction Press release from: ABNewswire Gauge Protection Design: Enhancing Drilling Performance and Wellbore Stability In tricone drill bit [ https://www.grandebit.com/tricone-bits/ ] design, gauge protection is a critical performance feature. To maintain stable wellbore diameters, particularly in challenging formations and hard rock conditions, advanced tricone bits incorporate various gauge protection mechanisms. These mechanisms not only reduce bit wear but also increase overall drilling efficiency. 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Additionally, the back of the bit cones is often reinforced with hardfacing and tungsten carbide inserts, enhancing the bit's wear resistance and overall gauge protection. Versatile Applications Across Industries Image: https://ecdn6.globalso.com/upload/p/365/image_product/2024-12/tricone-roller-bit-3.jpg With the growing demand for drilling solutions in various sectors, these new tricone drill bits are designed to meet the needs of different drilling applications. The following are some of the key product categories: - API Standard Tricone Bits [ https://www.grandebit.com/9-iadc-635-hard-rock-roller-cone/]: These bits adhere to API (American Petroleum Institute) standards and are designed primarily for oil and gas exploration. Their exceptional drilling performance and durability make them ideal for deep oil and gas wells. - Borewell Drilling Bits [ https://www.grandebit.com/kingdream-iadc437-9-1-2-tricone-rock-drill-bit-for-well-product/]: Specifically designed for water well drilling, these bits offer high efficiency in water resource extraction, widely used in agriculture, drinking water supply, and other water sourcing projects. - Mining Tricone Bits [ https://www.grandebit.com/5-1-4-iadc-637-537-small-drill-bit-for-hard-rock-drilling/]: These bits are built to withstand tough rock formations and are used in mining operations, including the extraction of precious metals, coal, and other minerals. Their robust construction ensures optimal performance in both soft and hard rock conditions. - Insert Tooth Drill Bits: Featuring tungsten carbide inserts, these bits are designed to perform in a wide range of soil and rock formations. They provide excellent cutting efficiency and long-lasting durability, even in challenging drilling environments. - Milled Tooth Tricone Bits: These bits are ideal for drilling through medium-hard and soft formations. The milled tooth design ensures smooth drilling with minimal vibration, preventing wellbore deviation and improving overall drilling efficiency. Custom Solutions for Specific Drilling Requirements As the demand for high-performance drill bits increases, manufacturers are offering customized solutions to meet specific drilling tasks and geological conditions. Customization can involve adjusting the bit design, including the tooth profile, material selection, and gauge protection features to suit unique drilling challenges, such as depth, rock hardness, and wellbore diameter. Image: https://ecdn6.globalso.com/upload/p/365/image_product/2024-12/tricone-roller-bit-5.jpgImage: https://ecdn6.globalso.com/upload/p/365/image_product/2024-12/tricone-roller-bit-6.jpg Some drill bits also feature composite gauge protection designs, combining different protective measures like exterior gauge inserts, hardfaced backs, and carbide teeth, to further enhance durability and cutting efficiency. These composite designs help extend the bit's service life, reduce wear, and improve overall drilling performance, offering significant cost savings in the long term. Conclusion As drilling technology advances, tricone drill bits continue to be essential tools in the drilling industry. Whether for oil and gas exploration, water well drilling, or mining operations, these new advanced tricone bits offer superior performance, excellent gauge protection, and high efficiency, addressing the diverse needs of modern drilling projects. With ongoing innovation and the development of custom solutions, tricone drill bits are expected to remain a cornerstone of drilling technology worldwide. For customers seeking to optimize their drilling operations, selecting the right tricone drill bit can significantly improve drilling efficiency, reduce operational costs, and extend the lifespan of drilling equipment, ensuring smooth project execution. Media Contact Company Name: TIANJIN GRAND CONSTRUCTION MACHINERY TECHNOLOGY CO., LTD. Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=gauge-protection-design-enhancing-drilling-performance-and-wellbore-stability ] Phone: +86 13920330362 Address:NO. 1 YANMEN ROAD City: TIANJIN Country: China Website: https://www.grandebit.com/ This release was published on openPR.Jim Harbaugh, Justin Herbert and the Los Angeles Chargers celebrated in the locker room Saturday after they wrapped up a playoff spot with a 40-7 victory over the New England Patriots . But even as they realized one goal by making the postseason, Harbaugh tried to keep things focused on the road ahead by stressing: “There's more to do.” The Chargers (10-6) go into the regular-season finale at Las Vegas knowing they will be at least the AFC's sixth seed and avoid a trip to Buffalo for the wild-card round. Los Angeles currently is in line to face Baltimore in a Harbaugh Bowl rematch, but it has an outside shot at the fifth seed and a trip to Houston if Cincinnati beats Pittsburgh next weekend. While Harbaugh credited his players for the turnaround from five wins last year to double-digit victories this season, Herbert gave most of it to Harbaugh and first-year general manager Joe Hortiz. “They have done such a great job of getting the right guys here. You look in the locker room and everybody plays for each other,” Herbert said. “(Harbaugh's) a competitor, and he wants to win no matter what it is. It definitely shows, and it’s the way everyone fights for him, wants to play for him, and respects him.” Harbaugh is the fifth coach in NFL history to win at least 10 games in his first season with two teams. He is also the eighth to make the playoffs in his first season with two teams. “Very little to do with me. If it goes right, then it’s our players. They’re doing a great job. It’s gone bad a couple times. That’s on me,” he said. “I’ve been drinking the Kool-Aid here from day one, I can’t give enough credit to Derwin James, Justin Herbert, and those two in particular. And Khalil Mack and Rashawn Slater. I mean, stalwarts. Brad Bozeman has come in. He’s been a stalwart. There’s a bunch. There’s probably, like — I counted it up early. There was maybe 15, 15 stalwarts that we had, and it’s grown since then.” Even though the Chargers are 3-5 against teams with winning records at the time they've played them, they are 7-1 against teams that were at or under .500. Four of those wins against opponents with losing records have come by at least 17 points, the first time since 2017 the Bolts have won that many games by as big a margin. Since halftime of their Dec. 19 game against Denver, the Chargers have outscored the Broncos and Patriots 61-13 over six quarters. “That’s the type of football we want to be playing in December, January, and hopefully on. That’s the type of football you want to be playing, especially in these big games like that. It was really good to see,” Herbert said. Offensive coordinator Greg Roman has said throughout the season it's tough to use the full playbook when the Chargers have short drives. They came into Saturday's game ranked 26th with only 23 possessions of at least 10 plays, but they had four against the Patriots, leading to three touchdowns and a field goal. It was the first time since Week 10 last season against Detroit they have had at least four drives of double-digit plays. Kickoff return coverage. The Chargers have allowed nine kick returns of at least 30 yards, eighth most in the league. New England's Alex Erickson had three returns for 90 yards, including 34 and 31 yards. RB J.K. Dobbins was activated off injured reserve and provided a boost to the offense with 76 yards on 19 carries and a touchdown. Dobbins, who missed four games due to a knee injury, has set career highs in scrimmage yards (983) and rushing yards (842) in his first season with the Chargers. WR D.J. Chark was targeted four times but didn't have a catch. Chark was signed during the offseason to provide experience and speed to a young receiver group. However, he missed the first half of the season with a hip injury and has played sparingly since his return. He has three receptions on the season. Three starters — RB Gus Edwards (ankle), LB Denzel Perryman (groin) and OG Trey Pipkins (hip) — were inactive. WR Joshua Palmer (heel) and DB Elijah Molden (shin) were injured in the second half. 77 and 1,054 — Receptions and receiving yards by Ladd McConkey, both records for a Chargers rookie. 5 — Consecutive seasons by Herbert with at least 3,000 passing yards and 20 touchdown passes, tied with Peyton Manning and Russell Wilson for the most to start a career. 2 — Sacks by Derwin James Jr. against the Patriots, the first time in the safety's seven-year career he has had multiple sacks in a game. The Chargers go for their first season sweep of the Raiders since 2018 in the regular-season finale. AP NFL: https://apnews.com/hub/NFL(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024AP Sports SummaryBrief at 6:24 p.m. EST

Russia’s ruble has fallen to its lowest level against the U.S. dollar since the beginning of its full-scale invasion of Ukraine , a potential result of new U.S. sanctions and the latest sign of a struggling wartime economy. Russia’s central bank said on Wednesday it would stop foreign currency purchases for the rest of the year after the ruble weakened beyond 110 rubles to the U.S. dollar, down by one-third since early August. “The decision was made to reduce the volatility of financial markets,” the regulator said in a statement. The ruble’s slide comes days after the U.S. on Thursday sanctioned Russia’s third largest bank, Gazprombank, and its six foreign subsidiaries, which have handled most foreign payments for natural gas exports. Earlier rounds of sanctions spared Russian gas because Europe’s economy was so dependent on it, but European countries have since lined up alternative supplies and are now far less reliant on Russian gas. The U.S. treasury and state departments said last week the new sanctions “will make it harder for the Kremlin to evade (existing) U.S. sanctions and fund and equip its military.” Canada and the United Kingdom have previously sanctioned Gazprombank. Dmitry Pyanov, deputy CEO of Russia’s second largest lender VTB, told Reuters the U.S. sanctions on Gazprombank likely “have had a significant impact” on the ruble “as it has ceased to be a channel for delivering foreign currency to the Moscow Exchange.” Russia’s finance minister, Anton Siluanov, told a financial conference in Moscow this week that a weak ruble was “very, very favourable” for exporters — suggesting the Kremlin may be content with letting the exchange rate slide. Russia published new economic data on Wednesday highlighting the latest signs of overheating in an economy retooled for the purpose of fighting the war in Ukraine, which has sucked workers out of the labour force. Real wages were up 8.4 per cent in September in year-on-year terms, unemployment hit a record low 2.3 per cent in October, and weekly inflation stands at almost 0.4 per cent. Overall inflation has remained stubbornly around eight per cent — twice as high as the central bank’s target. The bank last month raised its base interest rate to a record-high of 21 per cent in an effort to rein inflation in, but massive government spending on both the military and the struggling labour force has made it difficult. “One of the things that’s actually driving inflation is that they’re paying people so much money to go to the war, to recruit them,” said Lisa Sundstrom, a political science professor at the University of British Columbia who studies Russia, to Global News. “Even in domestic industries, they’re having to pay people really high salaries because they have a labour shortage.” The ruble’s fall could further fuel inflation, according to the central bank’s own estimates that predict a 10-per cent weakening of the currency adds 0.5 percentage points to inflation. That implies the four-month fall could add 1.5 per cent to the current rate. “For the central bank, it represents a challenge in combating rising prices,” economist Evgeny Kogan told Reuters. Chris Weafer, CEO at Macro-Advisory Ltd. consultancy, told the Associated Press last month the latest interest rate hike was “not so much a cry for help, but a scream of pain” from regulators. Independent Russian economists have said the economy is moving into a period of “stagflation” — a combination of high inflation and low growth. More than one-third of next year’s budget has been allocated toward the military-industrial complex as Moscow continues to press ahead with its war in Ukraine. Sundstrom said there could be an economic “crisis” if the war ends and that money is no longer flowing. “It’s not like business is going to come back immediately, I would think,” she said, adding some oligarchs and business leaders who opted to stay in Russia since the invasion began have begun to complain about the current state of the economy. “At the same time, if the war were to end, what are you going to do with all those soldiers who are being paid these enormous amounts of money?” she asked. “Do you just try to keep paying to them?” —with files from Reuters and the Associated Press