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r.go wifi vendo 1 CLEVELAND (AP) — Myles Garrett was in no mood to celebrate his birthday or making history. Garrett recorded two sacks to become the first NFL player with 14 sacks in four straight seasons, but the Cleveland Browns couldn't do anything on offense during a 20-3 loss to the Miami Dolphins on Sunday. Garrett turned 29 and turned in another stellar performance in this dreadful season for the Browns (3-13), who had hoped to take another step after making the playoffs a year ago. But nothing has gone right in Cleveland, and now the team is facing another offseason of change. Garrett has 14 sacks this season and 102 1/2 in his eight-year career. He's making the case for a second consecutive NFL defensive player of the year honor. But there isn't any award that will ease the pain of his fourth double-digit loss season. “At the end of the day, we play for wins,” Garrett said. “The individual stuff is great. It's nice, you want to be remembered for all of the above. But cities remember you for wins and bringing championships back home. “That's always been my intention. So, I want to get back on track, want to get back to winning, whether it's the last one or whatever's in store next season.” Garrett recently made it clear that he does not want to be part of another rebuild in Cleveland, saying he wanted to see the team's plans to improve the roster. His comments opened the possibility that he could ask for a trade if he isn't satisfied with the Browns' outlook. After the Browns dropped their fifth in a row to finish 2-6 at home, Garrett said he never considered that it might be his last game in Cleveland. “I don't think about that kind of stuff,” he said. “My mission is to go out there and try to help this team win as a leader, as a brother, as a teammate. That's what I solely focus on. I'm not looking into the future. Next thing on my mind is recovery, looking at film, how can we improve going to the Ravens and try to play spoiler for them.” Garrett hasn't given up. For the second week in a row, he displayed extraordinary effort while chasing a scrambling quarterback without getting a sack. He won't quit. “He's the best pass rusher in the game,” Browns guard Joel Bitonio said. “You could ask all the players, all the coaches. He's probably the guy they fear going up against the most. He's dynamic. He's a special player. He's doing his thing. I hope we can get some stuff around him so he can win some games around here.” Garrett twice went into the medical tent during the game. He slowly walked to his locker to get dressed before turning on some music that brought a little life into an otherwise somber Cleveland locker room. Garrett laughed when asked if he's pushing himself to the end. “I'm just old,” he said. “I'm 29. I'm not going to be dragging myself through the finish line. I'll be fine by Friday, Saturday and be ready to go. I always am." AP NFL: https://apnews.com/hub/NFL

Millions of Australians grew up by the beach and spent their summers playing in the surf, never knowing deadly critters could be lurking just below the waves. Keep reading to learn all about the world's most dangerous sea creatures, many of whom call the waters around Australia home. DOWNLOAD THE 9NEWS APP : Stay across all the latest in breaking news, sport, politics and the weather via our news app and get notifications sent straight to your smartphone. Available on the Apple App Store and Google Play . Striped pyjama squid are both venomous and poisonous; their bite contains a potent neurotoxin and their slime is poisonous, which they use as a defense mechanism to deter predators. Despite their names, these toxic little cephalopods are found in the waters around Australia, measure just 8cm in length and are actually not squid at all — they're cuttlefish. It's not yet known whether the slime is harmful to humans but it's probably a good idea to avoid handling or ingesting one anyway. Not only are crown-of-thorns starfish responsible for destroying coral reefs around the world, their venemous spines can also cause humans a world of pain. Growing up to 80 cm in diameter, these huge starfish's spines (which can be up to 4cm long) are covered in dangerous plancitoxins which can cause liver damage. They can also release dangerous saponins compounds when threatened, which destroy red blood cells. Humans stung by these intimidating-looking critters can suffer pain, vomiting, swelling and in rare cases, anaphylactic shock and death. It looks like something you'd find in an Aussie backyard but the bristleworm is actually a venomous sea creature. These little worms are covered in stiff, often venomous bristles which can break off easily when bumped or handled by humans. The venomous species, like the fireworm, can cause rashes, itching, burning pain, and swelling for several days after initial contact. It may not look like an animal but fire coral is actually a collection of colonial marine organisms. They vary in size, shape and colour but all are made up of hard skeletons packed with tiny pores which allow them to stretch stinging tentacles out into the water. Even the slightest brush against fire coral can leave humans in intense pain for days on end. This is because of the fire coral's venom, which can also cause side-effects like skin irritation, stinging or burning pain, redness, fever, and hives. Thankfully the sting is nonlethal to humans. They may be beautiful but lionfish are actually one of the more dangerous fish in the sea. Their tall dorsal spines aren't just for display — they're actually full of potent venom that can cause nausea, breathing difficulties and even paralysis in humans. Fortunately deaths from lionfish stings are very rare and usually only occur when the victim already had other existing medical issues. Sea snakes don't go after humans often but that doesn't mean these ocean predators aren't dangerous.  There are more than 70 species of sea snakes in the world, most of which are venomous, including this beaked sea snake which is loaded with venom even more potent than that of a cobra. Symptoms after a bite include headache, a thick-feeling tongue, thirst, sweating, and vomiting. Thankfully, most sea snakes rarely inject their venom when biting so human attacks and fatalities are rare. These killers hide in plain sight in reefs and shallow waters around Australia, though most beach-goers wouldn't notice them until it's too late. Stonefish are very ugly, very venomous creatures that use their expert camouflage to blend into the seafloor and coral so they can catch prey unaware. Unfortunately, they can also catch humans unaware with their sharp dorsal spines that are loaded with venom that only releases under pressure. Say, for example, when a human foot lands on them. Dozens of stonefish stings are recorded in Australia every year, however very few deaths have occurred since an antivenom was developed. Most scholars agree that blue-ringed octopuses have killed at least 11 people, though the true number could be as low as seven or as high as 16. Despite being tiny and fragile-looking, these Australian sea creatures carry enough venom to kill 26 adult humans within minutes. The venom produced in their salivary glands can cause nausea, respiratory arrest, heart failure, severe and sometimes total paralysis, blindness, and even death within minutes of a bite. The worst part is that the bite itself is often painless, so victims may not realise they've been bitten until paralysis begins. It looks like a pretty sea shell but picking this up off the ocean floor could land you in hospital. Cone snails are equipped with venom-filled modified teeth that work like harpoons, shooting out of their shells to paralyse prey with a single jab. Usually they feed on small fish, invertebrates and other cone snails but geography cone snails, which can grow up to 15cm long, are also dangerous to humans. Their venom is packed with an estimated 10,000 active compounds and can cause respiratory paralysis resulting in death. According to a 2016 study, they've killed about 15 people in the last 30 years. It's time for the sharks, starting with bull sharks. Credited with almost 120 known attacks on humans and at least 26 fatalities, bull sharks don't hunt people but encounters can be deadly. They are considered particularly dangerous due to their aggressive natures and ability to survive in both saltwater and freshwater environments. They've been found in rivers and creeks around Australia as well as in our ocean waters and tend to lurk in shallow waters, which increases the risk of run-ins with humans. Tiger sharks have killed about 40 people and are known to have attacked at least 140 humans. These sharks are territorial, aggressive and known to bite into just about anything, including people in some unfortunate circumstances. They often dwell near shallow reefs and in river mouths, bringing them closer to humans than shark species that stick to the open oceans. Though they're fearsome, tiger sharks don't hunt humans on purpose and only a few attacks are recorded each year. With over 350 known attacks and about 60 fatalities on record, the great white shark has long been considered one of the deadliest creatures in the ocean. These huge sea predators can grow to over six metres long and have mouths packed with serrated teeth, but they don't target human prey on purpose. In fact, many attacks on surfers over the years have been put down to cases of mistaken identity, as a human on a surfboard can appear like a seal to a great white shark swimming in the depths below. Even so, these intimidating sharks are best avoided. It's about the size of a fingernail and far less visually intimidating than the sharks and sea snakes on this list, but the most deadly creature in the sea is widely believed to be the box jellyfish. Box jellyfish are estimated to have caused at least 69 deaths since record keeping began in 1883 and one of the most well-known species is the Irukandji, which lives in the waters off Australia's north east. These tiny critters are among the most venomous jellyfish in the world, can cause fatal brain hemorrhages, and send between 50 and 100 people to the hospital every year.NUBURU, Inc. Receives Notice of Non-Compliance with the NYSE

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Drug-resistant infections may be a global killer, associated with nearly five million deaths a year, but a fifth of all these deaths occur in just one single country — India. Yet, despite this and being portrayed by the international community as the ground zero of the global antimicrobial resistance (AMR) crisis, India may be the heart of the solution. Because, given its scientific expertise, clinical resources and pharmaceutical sector, India has everything it needs to not only reverse the crisis within its own borders but also to lead the way in the global AMR response. AMR is a growing threat Such solutions are urgently needed because AMR has now reached an alarming tipping point. Having remained relatively flat for more than three decades, the global number of deaths associated with AMR is now expected to rise sharply. By the year 2050 it could increase by 70% and claim as many as 169 million lives. A key way to prevent this is by developing effective new treatments and ensuring that people get access to them. India is uniquely positioned to deliver on both of these, and, moreover, has a strong track record of doing so. During the height of the HIV/AIDS epidemic, and then again, more recently, with the COVID-19 pandemic, India became one of the foremost producers and global suppliers of affordable medicines and vaccines. Similarly, in recent years India has also significantly increased access to childhood immunisation and, thanks to the largest and most ambitious national immunisation campaign pre-COVID-19, has for more than a decade been polio-free, a feat many experts thought not possible. In theory, India can now have similar successes with AMR. Not just because it has the ability to develop much needed tools, such as new antibiotics, but also because it has all the key pieces in place required to develop the right antibiotics. This will be key as it will also help to address the chronic lack of access across the globe, which currently kills more people than drug-resistant infections. Poor access is partly the result of fewer antibiotics being developed and manufactured. But even so, long before pharmaceutical companies started to withdraw from the market, millions of people, particularly those living in low- and middle-income countries (LMICs), were not getting the antibiotics they needed either because they were priced out of reach, not registered in their country or simply were not being developed in the first place. In addition, antibiotics were often not approved or formulated for those populations most at risk, such as children and infants. Have dedicated R&D If we are to change this, then a radically different approach is needed — one involving a research and development (R&D) ecosystem geared entirely towards affordable antibiotics targeting those multidrug-resistant infections that pose the greatest public health threat. And it is hard to imagine a country in a better position to achieve this than India. First, there is India’s high burden of drug-resistant infections. The one advantage of this is that when trials or studies are carried out on larger and more relevant populations, the results tend to be a lot more robust. This is important not just in terms of ensuring that the right antibiotics are developed for the right kinds of drug-resistant infections, but also that they can be developed for groups which may be at high risk, but might otherwise be excluded from trials, such as newborns, women and people living with co-morbidities. Then there are India’s expert medical and scientific communities and its clinical trial networks. Under the auspices of the Indian Council of Medical Research (ICMR), these networks include research institutions and clinical research organisations which are helping to plug vital data gaps that are important for antibiotic development and introduction. Such trials can, for example, provide greater clarity on disease burden and antibiotic usage, and can help to identify solutions to important barriers to antibiotic access. The third essential piece is India’s highly innovative biotech and pharmaceutical industry, which, in addition to innovative R&D, has a long history of commercial partnerships and technology transfers. Given that many biotech companies developing antibiotics are small and lack any kind of manufacturing capabilities of their own, such partnerships are essential to take a drug beyond the initial R&D. In addition, there are signs that Indian-based biotechs and innovator companies may be emerging that can help address AMR. And from an access perspective, establishing a pathway between innovation and manufacturing is also critical because it includes all the necessary activities to ensure that an antibiotic can be manufactured and commercialised at an affordable price and in sufficient supply. In perspective The final piece of the puzzle is India’s huge population, and the high antibiotic need that comes with it, both of which conspire to make a sustainable market for antibiotics possible. Because for antibiotics to be both affordable and financially viable, sufficient volumes are needed, which is precisely what India has. Given that the historic decline of antibiotic R&D is often blamed on market failures, the economies of scale of India suggest that some markets can in fact succeed. The Global Antibiotic Research and Development Partnership (GARDP) is deeply involved with India, partnering with the ICMR as well as several pharmaceutical firms and manufacturers and carrying out studies within India. Because not only does India provide a way to tackle AMR differently but also because there is so much to gain from it. If the Government of India were to further embrace this, such as through additional funding for clinical trials, capital expenditure grants for pharmaceutical companies, import waivers for key manufacturing equipment and by implementing pooled procurement models for antibiotics, this would not only bode well for India but also for the rest of the world. Partly because if India is able to tackle AMR domestically it will have a big impact on AMR globally. But also if India, once again, takes on the role of the global supplier and even innovator of affordable life-saving drugs, it will pave the way for other countries to tackle AMR too. Dr. Manica Balasegaram is Executive Director, Global Antibiotic Research and Development Partnership (GARDP) Published - November 24, 2024 04:30 am IST Copy link Email Facebook Twitter Telegram LinkedIn WhatsApp Reddit prescription drugs / generic drugs / medicine / medical research / medical conditions / pharmaceutical / India / health treatment / Coronavirus / AIDS / vaccines / children / government / poliomyelitis / imports

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LOS ANGELES -- LeBron James has been ruled out of the Los Angeles Lakers' game at Minnesota on Friday night due to soreness in his left foot. James will miss his second straight game when the Lakers return from a four-day break to face the Timberwolves, the Lakers announced Thursday. The top scorer in NBA history was away from the team this week with an excused absence attributed to “personal reasons,” coach JJ Redick said Wednesday. It's unclear whether James will even make the quick round trip to Minnesota before the Lakers' next game at home against Memphis on Sunday. James missed his first game of his record-tying 22nd NBA season when the Lakers beat Portland at home last Sunday. That absence also was attributed to his foot injury. James is averaging 23.0 points, 9.1 assists and 8.0 rebounds for the Lakers (13-11), who have lost seven of 10 after a 10-4 start. The Lakers upgraded starter Austin Reaves to questionable for the game at Minnesota after he missed LA's previous five games with a pelvic bruise. Anthony Davis is listed as probable with left plantar fasciitis. ___ AP NBA: https://apnews.com/NBAIna Garten isn't serving up sour grapes — but she's setting the record straight. The 76-year-old Food Network alum addressed Martha Stewart's claim that the two fell out after Stewart, 83, went to prison in October 2004. (Stewart spent five months behind bars after being found guilty on charges including conspiracy and obstruction of justice related to the sale of a stock — she was released in March 2005.) "Well, let's just say her story isn't exactly accurate," Garten told People during a Q&A on Thursday, December 5. Laughing, she added, "And, you know, that was 25 years ago. I think it's time to let it go." Earlier this year, Stewart painted a different picture of their friendship's end. "When I was sent off to Alderson Prison, she stopped talking to me," the lifestyle guru told The New Yorker in September, calling it "extremely distressing and extremely unfriendly." Garten, however, has maintained that distance — not drama — caused the rift. She explained to the outlet that their relationship fizzled when she moved to Connecticut and her former friend stayed in New York. A post shared by People Magazine (@people) When a clip of Garten's recent Q&A hit social media, fans were quick to weigh in. "Love you Ina!!! But I do believe Martha was telling the truth..." one person commented. "This is not easy for me since I am huge fans of both. There are always two sides to a story," another fan added. "Not everyone likes everyone. Ina is right, move on," chimed in a third. The two domestic icons go way back. Stewart helped launch Garten's career in the early 1990s by writing about her Hamptons food store, The Barefoot Contessa, in the first issue of Martha Stewart Living. That article connected Garten with her future publisher, Chip Gibson, and led to her first cookbook. Despite their history, Stewart told People in October that a reconciliation seemed unlikely. "She's into her own thing," the culinary queen said. "That's okay." Still, the two haven't shied away from complimenting each other over the years. "I think she did something really important," the Be Ready When the Luck Happens author said of Stewart in 2017 , praising her for elevating home arts to a level of prestige.None